Patents and Licenses

Cycle sequencing method with 3 dNTPs - Method of use is covered by one or more of the following patent(s): US Patent No. 5,674,679 and 5,741,640.

Exonuclease I/Shrimp Alkaline Phosphatase - This product is licensed under U.S. Patent Numbers: 5,741,676 and 5,756,285, and corresponding patents issued in other countries. Purchase of this product includes a license to use this product in a restricted way within the scope of rights granted to USB by GE Healthcare. No other license is granted to the purchaser either directly or by implication, estoppel or otherwise.

ExoSAP-IT - is covered by U.S. Patent Numbers: 6,379,940 and 6,387,634.

FideliTaq DNA Polymerase - Technology is licensed under U.S. Patent No. 5,436,149 owned by TaKaRa Bio Inc.

Glycol/heat denaturation method - This product and/or its method of use is covered by one or more of the following patent(s): US Patent No. 5,500,339 and foreign equivalents.

Glycerol Tolerant Gel Buffer - This product and/or its method of use is covered by US Patent No. 5,314,595.

HotStart-IT Taq DNA Polymerase - Patent pending.

miRtect-IT miRNA Labeling and Detection Kit - Patent pending. 

Mn Buffer - This reagent is suitable for use under one or more U.S. Patent Numbers: 4,795,699; 4,962,020 and 4,994,372. Patents pending in the U.S. and other countries.

Mut S, H, L Proteins - These products and/or method of use are covered by US Patent Numbers: 5,459,039; 5,556,750; 5,679,522; 5,702,894; 5,858,754; 5,861,482; 5,922,539 and 6,008,031.

The Polymerase Chain Reaction (PCR) is covered by patents owned by Roche Molecular Systems and F. Hoffmann-La Roche Ltd.

PrepEase products are covered under European Patent EP 0496822 and US Patent 6,428,703.

Pyrophosphatase - This product and/or its method of use is covered by one or more of the following patent(s): US patent number 5,498,523 and foreign equivalents.

Rodeo Sensitive Detection Reagent 1 - is Lumigen APS-5 Substrate. Lumigen APS-5 Substrate is covered by the following patents: U.S. Patents: 5,922,558; 6,045,727; 6,090,571and patents: AU 716233, 733086, CA 2213317, EP 819119B1, JP 3169383, KR 10-259144.

RapidGel - Covered under U.S. Patent No. 5,700,365.

Sequenase DNA Polymerase License - This product is sublicensed from GE Healthcare. The purchase of this kit (reagent) includes a limited non-exclusive sublicense under certain patents to use the kit (reagent) to perform a patented DNA sequencing method in those patents soley for use with Sequenase DNA ploymerase purchased from USB Corporation for research activities. Use of this kit (reagent) for commercial activities is not licensed. By way of example, but not by way of limitation, this license does not grant rights to use the kit (reagent) (1) for any procedure involving the diagnosis, treatment, prevention or mitigation of disease or other health-related condition or involving the detection of pathogens or genetic traits for medical uses; (2) for agriculture or veterinary medicine; (3) for cloning or producing nucleotide sequences for commercial sale. No other license is granted expressly, impliedly or by estoppel. For information concerning availablility of additional licenses to practice the patented methodologies, contact: GE Healthcare UK Limited, VP Corporate Development, Amersham Place, Little Chalfont, Buckinghamshire, HP7 9NA England.

Sequenase DNA Polymerase - This reagent (kit) is covered by or suitable for use under one or more US Patent Numbers: 4,795,699; 4,946,786; 4,942,130; 4,962,020; 4,994,372; 5,145,776; 5,173,411; 5,266,466; 5,409,811; 5,498,523; 5,639,608 and 5,674,716. Patents pending in US and other countries.

SYBR - is a registered trademark of Molecular Probes, Inc. and is provided under an agreement with Molecular Probes, Inc.

T4 Endonuclease VII - This product and/or its methods of use are covered by US Patent Nos.: 5,824,530; 5,698,400; 5,851,770 and 5,958,692.

Taq DNA Polymerase - Use of this product is covered by one or more of the following US patents and corresponding patent claims outside the US:  5,079,352, 5,789,224, 5,618,711, 6,127,155 and claims outside the US corresponding to US Patent No. 4,889,818.  The purchase of this product includes a limited, non-transferable immunity from suit under the foregoing patent claims for using only this amount of product for the purchaser’s own internal research. No right under any other patent claim (such as the patented 5’ Nuclease Process claims in US Patents Nos. 5,210,015 and 5,487,972), no right to perform any patented method, and no right to perform commercial services of any kind, including without limitation reporting the results of purchaser's activities for a fee or other commercial consideration, is conveyed expressly, by implication, or by estoppel. This product is for research use only. Diagnostic uses under Roche patents require a separate license from Roche. Further information on purchasing licenses may be obtained by contacting the Director of Licensing, Applied Biosystems, 850 Lincoln Centre Drive, Foster City, California 94404, USA.

Thermo Sequenase DNA Polymerase Manual Sequencing Kit License - Products containing Thermo Sequenase DNA Polymerase are sublicensed from GE Healthcare. The purchase of this kit (reagent) includes a limited non-exclusive sublicense under certain patents to use the kit (reagent) to perform one or more patented DNA sequencing methods in those patents solely for use with Thermo Sequenase DNA Polymerase purchased from GE Healthcare and/or its subsidiaries for research activities. No other license is granted expressly, impliedly or by estoppel. For information concerning availability of additional licenses to practice the patented methodologies, contact GE Healthcare UK Limited, VP Corporate Development, Amersham Place, Little Chalfont, Buckinghamshire, HP7 9NA England.

Thermo Sequenase DNA Polymerase - This reagent (kit) is covered by or suitable for use under one or more US Patent Numbers 4,962,020; 5,173,411; 5,409,811; 5,498,523; 5,614,365 and 5,674,716. Patents pending in US and other countries.

Tth DNA Polymerase – sold under licensing arrangements with Roche Molecular Systems, Inc. Purchase is accompanied by a limited license to use it in the Polymerase Chain Reaction (PCR) process in conjunction with a thermal cycler whose use in the automated performance of the PCR process is covered by the up-front license fee, either by payment to Perkin-Elmer or as purchased, i.e., an authorized thermal cycler.

Uracil-DNA Glycosylase - (UDG) – Purchase of this product is accompanied by a limited license under U.S. Patent Nos. 5,035,996; 5,683,896; 5,945,313; 6,518,026 and 6,287,823 and corresponding foreign patents.

Trademarks

USB, USB logo design, ExoSAP-IT, and PrepEase are registered trademarks of USB Corporation.

The phrases Fueling Innovation, Fueling Innovation in Life Science, and Your Partner in Fueling Innovation are trademarks of USB Corporation.

A-Taq-IT, Blunt-IT, Celufil, Change-IT, FideliTaq, Genetic Performance Certified, Hi-Res, HotStart-IT, Indigal, Ligate-IT, miRtect-IT, OptiKinase, RapidRun, Rodeo, RubyTaq, Tested User Friendly and Vitafree are trademarks of USB Corporation.

Alexa Fluor is a registered trademark of Molecular Probes, Inc.
Alician Blue is a registered trademark of ICI Americas Inc.
Amdex is a trademark of Amdex A/S.
Amerlex is a trademark of Johnson & Johnson.
APET, Kodak, BioMax and X-Omat are trademarks of Eastman Kodak Company.
Aureomycin is a trademark of Lederle Laboratories.
BioRobot is a registered trademark of Qiagen GmbH.
Bluescript is a trademark of Strategene Inc.
Brij is a registered trademark of ICI Americas Inc.
Coomassie is a registered trademark of the ICI Group.
Corex is a trademark of Corning.
Deep Vent is a trademark of New England Biolabs, Inc.
Ferene is a registered trademark of Diagnostic Chemicals Limited.
Ficoll is a registered trademark of Pharmacia Biotech AB.
Fluo-peptide is a trademark of Advance Bioconcept Ltd.
FPLC is a trademark of GE Healthcare Bio-Sciences
FragEL is a trademark of Calbiochem-Novabiochem Corp.
Gilson Pipetman is trademark of Gilson SA.
Hyamine is a treademark of Rohm & Haas Co.
Hyperfilm, RapidGel, Redivue, Sequenase and Thermo Sequenase are trademarks of GE Healthcare
Igepal is a trademark of Rhone-Polenc Surfactants and Specialties.
Lumigen is a registered trademark of Lumigen, Inc.
LUX is a trademark of Invitrogen.
MyiQ is a trademark of Bio-Rad.
Mylase ME is a trademark of Caribbean Pharaceuticals N.V.
Nalgene is a trademark of Nalge Nunc International.
Nonidet is a registered trademark of Shell.
Norit is a registered trademark of American Norit Company, Inc.
Parafilm is a registered trademark of American National Can.
Perspex is a trademark of ICI Group.
Pharmacia is a trademark of Pharmacia Corporation
Photobiotin is a trademark of Biotechnology Research Enterprises S. A. Pty. Ltd.
Plexiglas is a trademark of Rohm Gesellschaft & Haas Co.
Polaroid is a trademark of Polaroid (UK) Ltd.
ROX is a trademark of Applera Corporation or its subsidiaries in the U.S. and certain other countries.
SaranWrap is a trademark of Dow Chemical Corp.
Sarkosyl is a registered trademark of Ciba-Geigy, U.K. Limited.
Sepharose is a trademark of GE Healthcare Bio-Sciences
SNP-IT, SNP-IT Clean-Up, SNP-IT Clean-Up Diluent and SNPware are trademarks of Orchid BioSciences Inc., and used under license.
SpeedVac is a registered trademark of Savant.
Superscript and Geneticin are trademarks of Life Technologies Inc.
SYBR is a registered trademark of Molecular Probes, Inc.
TaqMan is a registered trademark of Roche Molecular Systems, Inc.
Teflon is a trademark DuPont.
Tetrad is a trademark of MJ Research, Inc.
Texas Red is a registered trademark of Molecular Probes, Inc.
TOPO is a registered trademark of Invitrogen.
Triton is a registered trademark of Union Carbide Chemicals and Plastics Company.
Tween is a registered trademark of the ICI Group.
Whatman is a registered trademark of Whatman Paper, Ltd.
Zwittergent is a registered trademark of EMD Biosciences, Inc.